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Much of the research on hallucinogenic drugs such as LSD has focused on the neurotransmitter serotonin, a chemical that when released from a presynaptic serotonin-secreting neuron causes the transmission of a nerve impulse across a synapse to an adjacent postsynaptic, or target, neuron. There are two major reasons for this emphasis. First, it was discovered early on that many of the major hallucinogens have a molecular structure similar to that of serotonin. In addition, animal studies of brain neurochemistry following administration of hallucinogens invariably reported changes in serotonin levels.
Early investigators correctly reasoned that the structural similarity to the serotonin molecule might imply that LSD`s effects are brought about by an action on the neurotransmission of serotonin in the brain. Unfortunately, the level of technical expertise in the field of brain research was such that this hypothesis had to be tested on peripheral tissue (tissue outside the brain). Two different groups of scientists reported that LSD powerfully blockaded serotonin`s action. Their conclusions were quickly challenged, however. We now know that the action of a drug at one site in the body does not necessarily correspond to the drug`s action at another site, especially when one site is in the brain and the other is not.
By the 1960`s, technical advances permitted the direct testing of the hypothesis that LSD and related hallucinogens act by directly suppressing the activity of serotonin-secreting neurons themselves-the so- called presynaptic hypothesis. Researchers reasoned that if the hllucinogenic drugs act by suppressing the activity of serotonin-secreting neurons, then drugs administered after these neurons had been destroyed should have no effect on behavior, because the system would already be maximally suppressed. Contrary to their expectations, neuron destruction enhanced the effect of LSD and related hallucinogens on behavior. Thus, hallucinogenic drugs apparently do not act directly on serotonin-secreting neurons.
However, these and other available data do support an alternative hypothesis, that LSD and related drugs act directly at receptor sites on serotonin target neurons (the postsynaptic hypothesis). The fact that LSD elicits "serotonin syndrome" -that is, causes the same kinds of behaviors as does the adminis- tration of serotonin-in animals whose brains are depleted of serotonin indicates that LSD acts directly n serotonin receptors, rather than indirectly through the release of stores of serotonin. The enhanced effect of LSD reported after serotonin depletion could be due to a proliferation of serotonin receptor sites on serotonin target neurons. This phenomenon often follows neuron destruction or neurotransmitter depletion; the increase in the number of receptor sites appears to be a compensatory response to decreased input. Significantly, this hypothesis is supported by data from a number of different laboratories.
[阅读&逻辑 ]新版冲分救命题 -11894
Select the sentence that presents a conventional requirement that is rejected by the author of the passage.
[阅读&逻辑 ]精选题 -11861
Which of the following, if true of the cave, most weakens the argument?
[阅读&逻辑 ]精选题 -11860
It can be inferred that the “sediments
[阅读&逻辑 ]精选题 -11859
Which of the following best describes the issue raised by the question in the highlighted portion of the passage?
[阅读&逻辑 ]精选题 -11858
It can be inferred that which of the following is true of the “geologic evidence”?
[阅读&逻辑 ]精选题 -11857
Which of the following elements in the debate over the origin of Varanus is NOT provided in the passage?
[阅读&逻辑 ]精选题 -11856
It can be inferred from the passage that the geographical distribution of the Komodo dragon is
[阅读&逻辑 ]精选题 -11855
Which of the following, if discovered to be true, would most tend to suggest that the “correlation” mentioned in the passage held true for the people of the West Branch site?
[阅读&逻辑 ]精选题 -11854
The final sentence of the passage primarily serves to do which of the following?
[阅读&逻辑 ]精选题 -11853
The passage implies which of the following about beavers?
[阅读&逻辑 ]精选题 -11852
The passage provides support for which of the following statements about beaver dams?
[阅读&逻辑 ]精选题 -11851
According to the passage, which of the following best accounts for the apparent bias in antelope-migration direction?
[阅读&逻辑 ]精选题 -11850
The author of the passage implies that during the
[阅读&逻辑 ]精选题 -11849
According to the passage, which of the following is true of an Eurasia-Africa land bridge during ice ages?
[填空 ]精选题 -11843
The political upheaval caught most people by surprise: despite the ______ warning of some commentators, it had never seemed that imminent.
[填空 ]精选题 -11842
Even if the story now seems a surprisingly innocuous overture to the author’s later, more fully developed narrations, it ____ some of the key traits of those bleaker tales.
[填空 ]精选题 -11841
William Perkins, his ______ speaking style notwithstanding, has long been seen as the moderate face of his political party.
[填空 ]精选题 -11840
Just because, as a photographer, Friedlander (i)____ places that most people consider ugly does not mean that he is out to prove they are beautiful. Instead, his work suggests that the photographer simply cannot ignore so much of the built American landscape but is obligated to (ii)_____ what we pass through day in and day out, regardless of (iii)_____.
[填空 ]精选题 -11839
In the search for truth, the knowledge gained by scientists consists of approximations with varying degrees of certainty. Such (i)_____ truth can be highly (ii)_____, as the rapid and relatively steady progress of medical knowledge well exemplifies.
[填空 ]精选题 -11838
History teaches us that science is not _________ enterprise, indeed, it is quite the opposite, a motley assortment of tools designed to safeguard researchers against their own biases.
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