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Much of the research on hallucinogenic drugs such as LSD has focused on the neurotransmitter serotonin, a chemical that when released from a presynaptic serotonin-secreting neuron causes the transmission of a nerve impulse across a synapse to an adjacent postsynaptic, or target, neuron. There are two major reasons for this emphasis. First, it was discovered early on that many of the major hallucinogens have a molecular structure similar to that of serotonin. In addition, animal studies of brain neurochemistry following administration of hallucinogens invariably reported changes in serotonin levels.
Early investigators correctly reasoned that the structural similarity to the serotonin molecule might imply that LSD`s effects are brought about by an action on the neurotransmission of serotonin in the brain. Unfortunately, the level of technical expertise in the field of brain research was such that this hypothesis had to be tested on peripheral tissue (tissue outside the brain). Two different groups of scientists reported that LSD powerfully blockaded serotonin`s action. Their conclusions were quickly challenged, however. We now know that the action of a drug at one site in the body does not necessarily correspond to the drug`s action at another site, especially when one site is in the brain and the other is not.
By the 1960`s, technical advances permitted the direct testing of the hypothesis that LSD and related hallucinogens act by directly suppressing the activity of serotonin-secreting neurons themselves-the so- called presynaptic hypothesis. Researchers reasoned that if the hllucinogenic drugs act by suppressing the activity of serotonin-secreting neurons, then drugs administered after these neurons had been destroyed should have no effect on behavior, because the system would already be maximally suppressed. Contrary to their expectations, neuron destruction enhanced the effect of LSD and related hallucinogens on behavior. Thus, hallucinogenic drugs apparently do not act directly on serotonin-secreting neurons.
However, these and other available data do support an alternative hypothesis, that LSD and related drugs act directly at receptor sites on serotonin target neurons (the postsynaptic hypothesis). The fact that LSD elicits "serotonin syndrome" -that is, causes the same kinds of behaviors as does the adminis- tration of serotonin-in animals whose brains are depleted of serotonin indicates that LSD acts directly n serotonin receptors, rather than indirectly through the release of stores of serotonin. The enhanced effect of LSD reported after serotonin depletion could be due to a proliferation of serotonin receptor sites on serotonin target neurons. This phenomenon often follows neuron destruction or neurotransmitter depletion; the increase in the number of receptor sites appears to be a compensatory response to decreased input. Significantly, this hypothesis is supported by data from a number of different laboratories.
哈士奇和鸡阿姨
[数学 ]【新版】冲分救命题 -11998
The integers a, b, and c are positive, and a>b>c. When a, b, and c are divided by 3, the remainders are 0, 1, and 1, respectively.
[数学 ]【新版】冲分救命题 -11997
For all positive even integers n. n* represents the product of all even integers from 2 to n, inclusive. For example, 12*=12×10×8×6×4×2. What is the greatest prime factor of 20*+22*?
[数学 ]【新版】冲分救命题 -11996
[数学 ]【新版】冲分救命题 -11995
[数学 ]【新版】冲分救命题 -11994
In a game, the cards in a certain deck are distributed to players one at a time until each player has the same number of cards and there are not enough cards left in the deck to distribute one more card to each player. The number of cards in the deck is between 60 and 100. If the cards in the deck are distributed o 5 players, 2 cards will be left in the deck. If the cards in the deck are distributed to 6 players, 4 cards will be left in the deck. If the cards in the deck are distributed to 7 players, how many cards will be left in the deck?
[数学 ]【新版】冲分救命题 -11993
Let a be the greatest integer such that is a factor of 1,500, and let b be the greatest integer such that is a factor of 33,333,333. Which of the following statements are true? Indicate all such statements.
[数学 ]【新版】冲分救命题 -11992
A set consists of all three-digit positive integers with the following properties.Each integer is of the form JKL,where J,K,and I are digits;all the digits are nonzero;and the two-digit integers JK and KL are each divisible by 9.How many integers are in the set?
[数学 ]【新版】冲分救命题 -11991
[数学 ]【新版】冲分救命题 -11990
The number of children in a certain family is a prime number less than 10. The number of boys in the family is greater than the number of girls, and the number of boys is a prime number. If at least 1 of the children in the family is a girl, which of the following could be the number of boys in the family?Indicate all such numbers.
[数学 ]【新版】冲分救命题 -11989
[数学 ]【新版】冲分救命题 -11988
x and y are integers.
[数学 ]【新版】冲分救命题 -11987
x and y are integers.
[数学 ]【新版】冲分救命题 -11986
a and b are distinct odd prime numbers.
[数学 ]【新版】冲分救命题 -11985
When the integer n is divided by 33, the remainder is 24. Which of the following must be a divisor of n?
[数学 ]【新版】冲分救命题 -11984
4.What is the length of an edge of the smallest solid cube that can be made by placing together solid rectangular blocks of size 7 by 6 by 3?
[数学 ]【新版】冲分救命题 -11983
Light travels at approximately 186,000 miles per second.Which of the following is closest to the number of miles that light travels in 3 hours.
[数学 ]【新版】冲分救命题 -11982
The number n is the least positive integer for which 108n is the square of an intege
[数学 ]【新版】冲分救命题 -11981
The number n is the least positive integer for which 108n is the square of an intege
[数学 ]【新版】冲分救命题 -11980
If x=2y+1, and y=2w, where w, x, and y are integers, which of the following must be an odd integer?
[数学 ]OG -11979
If x=2y+1, and y=2w, where w, x, and y are integers, which of the following must be an odd integer?
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